the association between androgenic hormone levels and the risk of developing coronary artery disease (cad)

نویسندگان

farzad allameh

gholamreza pourmand

ali bozorgi

sepideh nekuie

چکیده

background: the aim of the study was to evaluate the relationship between the serum levels of androgens and coronary artery disease (cad) in an iranian population. methods: male individuals admitted to tehran heart center and sina hospital, tehran, iran from 2011-2012 were categorized into cad and control groups based on selective coronary angiography. baseline demographic data, including age, bmi, diabetes, and a history of hypertension were recorded. patients were also assessed for their serum levels of total testosterone, free testosterone, estradiol, dehydroepi and rosterone sulfate (dhea-s), and sex hormone binding globulin (shbg). data analysis was carried out chi-square and anova tests as well as logistic regression analysis. results: two hundred patients were in the cad group and 135 individuals in control group. in the cad group, 69 had single-vessel disease, 49 had two-vessel diseases, and 82 had three-vessel diseases. statistically significant differences were observed between the individuals in the two groups with respect to age ( p <0.0001), diabetes ( p <0.0001), and a history of hypertension ( p =0.018). the serum levels of free testosterone ( p =0.048) and dhea-s ( p <0.0001) were significantly higher in the control group than in the cad group; however, the serum level of shbg was higher in the cad group than in the control group ( p =0.007). results of the logistic regression analysis indicated that only age ( p =0.042) and diabetes ( p =0.003) had significant relationships with cad. conclusion: although the serum levels of some of the androgens were significantly different between the two groups, no association was found between androgenic hormone levels and the risk of cad, due mainly to the effect of age and diabetes.

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

The Association between Androgenic Hormone Levels and the Risk of Developing Coronary Artery Disease (CAD).

BACKGROUND The aim of the study was to evaluate the relationship between the serum levels of androgens and Coronary Artery Disease (CAD) in an Iranian population. METHODS Male individuals admitted to Tehran Heart Center and Sina Hospital, Tehran, Iran from 2011-2012 were categorized into CAD and control groups based on selective coronary angiography. Baseline demographic data, including age, ...

متن کامل

A preliminary study of the association between the ABCA1 gene promoter DNA methylation and coronary artery disease risk

Coronary artery disease (CAD) is a common health problem in Iranian population. ATP binding cassette transporter A1 (ABCA1) plays central role in the efflux of the cholesterol from peripheral tissues back to liver. Inactivation of ABCA1 by epigenetic change such as DNA methylation may contribute to the development of CAD. The present study investigated the association between promoter DNA methy...

متن کامل

Association between myeloperoxidase levels and risk of coronary artery disease.

CONTEXT Myeloperoxidase (MPO), a leukocyte enzyme that promotes oxidation of lipoproteins in atheroma, has been proposed as a possible mediator of atherosclerosis. OBJECTIVE To determine the association between MPO levels and prevalence of coronary artery disease (CAD). DESIGN, SETTING, AND PATIENTS Case-control study conducted from July to September 2000 in a US tertiary care referral cent...

متن کامل

Association study between DNA methylation and genetic variation of APOE gene with the risk of coronary artery disease

Coronary artery disease (CAD) is a common health problem with a high rate of disability and death. Dyslipidemia and altered metabolism of Apo-lipoproteins are involved in the CAD pathogenesis. The current study investigated two common polymorphisms (rs429358 and rs7412) and promoter DNA methylation status of APOE in the Iranian CAD patients and control subjects. Two hundred angiographi...

متن کامل

Association between Helicobacter pylori Infection and Atherosclerotic Coronary Artery Disease

  Background and Objectives: Cardiovascular disease is the most common cause of death in developed countries. In addition to traditional risk factors for cardiovascular disease, nowadays, accumulating evidence indicates that a variety of infections contribute to pathogenesis of atherosclerosis,  (We investigated whether Helicobacter pylori infection is related to Prevalence of coronar...

متن کامل

منابع من

با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید


عنوان ژورنال:
iranian journal of public health

جلد ۴۵، شماره ۱، صفحات ۱۴-۱۹

میزبانی شده توسط پلتفرم ابری doprax.com

copyright © 2015-2023